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| Lange,Marcela Kist; Heberlé,Graziela; Milão,Denise. |
| Vários são os fatores que podem ocasionar a instabilidade de uma emulsão, destacando-se a oxidação, reação prevenida pelo emprego de antioxidantes. O butil-hidróxi-tolueno (BHT) tem sido um dos antioxidantes sintéticos mais utilizados em formulações cosméticas, porém, a busca da indústria farmacêutica e cosmética pelo emprego de produtos de origem natural tem sido cada vez maior. Visto isso, o objetivo do presente trabalho foi a incorporação do resveratrol, um composto fenólico encontrado principalmente em uvas bem como em vinhos tintos, em uma emulsão base não-iônica para avaliação do perfil de estabilidade e atividade antioxidante em comparação a uma emulsão base não-iônica contendo o BHT. O perfil de estabilidade foi analisado pela observação das... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Emulsões/estabilidade; Antioxidantes; Butil-hidróxi-tolueno; Resveratrol. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100018 |
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| Noriega-González,J. E; Chirino,Y. I; Mata-Miranda,M. M; Vázquez-Zapién,G. J; Sánchez-Monroy,V. |
| Obesity has reached epidemic proportions, the World Health Organization (WHO) estimates that there are more than 1,000 million overweight adults world-wide. Furthermore, obesity is characterized as an overgrowth of white adipose tissue as a result of adipocyte hypertrophy and hyperplasia. Mitochondria is considered the source of energy within the adipocyte, since it contains the molecular machinery, and it is involved in a large number of metabolic pathways, besides the transformation of chemical energy into adenosine triphosphate. Mitochondria shortage and adipocyte dysfunction result in an excessive accumulation of triacylglycerol in the cytoplasm, which determines an imbalance between energy production and energy expenditure. Resveratrol (RSV) is a... |
| Tipo: Journal article |
Palavras-chave: Preadipocytes; Differentiated mature adipocyte; Mitochondrial activity; Resveratrol. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300044 |
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| Almeida,Tamires Cunha; Seibert,Janaina Brandão; Almeida,Sávio Henrique de Souza; Amparo,Tatiane Roquete; Teixeira,Luiz Fernando de Medeiros; Barichello,Jose Mario; Postacchini,Bruna Bueno; Santos,Orlando David Henrique dos; Silva,Glenda Nicioli da. |
| Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Cytotoxic activity; F127®; Polymeric micelles; Resveratrol. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100567 |
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| Zhang,CY; Huang,J; Kang,XT. |
| ABSTRACT This study aims to investigate whether resveratrol (RES) could inhibit NF-κB activity and protect in vitro cultured chicken lymphocytes from apoptosis induced by continuous LPS stimulation. Blood lymphocytes of chickens were collected and cultured. LPS was added to the samples of treatment group, while the same volume of normal saline (NS) was supplemented to those of the control group. In the treatment groups, four different concentrations of RES (0, 20, 40, and 80 µg/ml) were admixed. Then, the following indicators were tested: lymphocyte apoptotic rate, lymphocyte viability, NF-κB activity, TNF-a level, reactive oxygen species (ROS), and expression of apoptosis-related proteins (Fas/FasL and Caspase-8). The results indicated that the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Resveratrol; NF-κB; Lymphocyte apoptosis; Chicken. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2018000400747 |
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| Turkez,Hasan; Aydin,Elanur. |
| The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chromosome aberration; Mutagenicity; Permethrin; Resveratrol; Sister chromatid exchange. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008 |
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| van der Spuy,Wendy Jeannette; Pretorius,Etheresia. |
| Dysferlinopathy is a form of muscular dystrophy affecting muscles of the shoulder and pelvic girdles, resulting from inheritance of a mutated dysferlin gene. The encoded dysferlin protein is proposed to be involved in sarcolemmal vesicle fusion with a disrupted plasma membrane; however, with defective protein function these vesicles accumulate beneath the disruption site but are unable to fuse with it and reseal the membrane, thus rendering the membrane repair mechanism defective. The SJL/J mouse model presents with characteristics much like the commonest human condition. Immune modulators have long been under study in the maintenance of muscle health in muscular dystrophies. Such supplementary treatment would ideally suppress inflammation, preventing the... |
| Tipo: Journal article |
Palavras-chave: Dysferlinopathy; Coenzyme Q10; Resveratrol; Sarcolemma. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300035 |
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